Sebclair: A Non-Steroidal Cream for the treatment of Seborrheic Dermatitis

Sinclair Pharmaceuticals Ltd

Introduction/Background

Seborrheic dermatitis is a common dermatological condition that affects areas of the body with a particularly high concentration of sebaceous glands. This may include the eyebrows, bridge of the nose, naso-labial folds, ears and chest. It manifests as erythema (reddening), which progresses to flakiness and at its most severe, crusting of the skin. Seborrheic dermatitis of the scalp is also particularly common, and commonly referred to as dandruff. It is estimated to occur in 3-5% of the general population. It is common in young adult men, and the under-5s, where it may manifest as 'cradle cap'. Topical corticosteroids are commonly used for seborrheic dermatitis, however their side-effects are unwelcome, particularly on facial skin where this condition is very common.

Aims/Hypothesis

Sinclair is currently developing a novel non-steroidal cream for the treatment of seborrheic dermatitis.

Research

Sebclair is a non-steroidal cream, indicated for the management of seborrheic dermatitis, including relief and management of the most common signs and symptoms such as scaling/flaking, erythema (reddening), burning and pain. The product is designed to moisturise and reduce the affected areas of skin without the steroidal adverse effects that are particularly unwelcome on facial skin.

Sinclair has also been informed by the FDA that Sebclair will be designated in the US in its current configuration as a drug rather than a medical device because of the presence of salicylic acid. The Company?s expectation for the launch of Sebclair in 2006 is not affected by this decision as the Company has alternative formulations of Sebclair, which do not require salicylic acid, which will now be substituted.

Conclusion

Sebclair is a novel treatment for seborrheic dermatitis.

Relevance/Opportunity

Sebclair offers the benefit of being steroid-free and thus being useable on the face without concern and not carrying any of the well known side effects of topical steroids. Sinclair is currently seeking exclusive distributors to market Sebclair in key territories around the world.